When David Shorr was 56, the then-mortgage consultant in Columbus, OH, noticed some changes in his memory and thinking.

Three years later, the 59-year-old searches for the words to describe it. “It wasn’t sudden, but over time, I knew in my mind that something was different. I wasn’t able to manage some of the stuff that I had been doing before.” He speaks slowly and carefully. “I found that people were seeing what was going on with me. As that went on, it came to a head. I was diagnosed with Alzheimer’s.

David Shorr and his wife, Kim, went to the Ohio State University Wexner Medical Center for treatment. David Shorr got medications to ease some of the symptoms. But without medicines to cure or slow the progress of the disease, their only other option was experimental treatments.